Ariamala Gopalsamy: search on Z-Library

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1

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Gopalsamy, Ariamala, Aulabaugh, Ann E., Barakat, Amey, Beaumont, Kevin C., Cabral, Shawn, Canterbury, Daniel P., Casimiro-Garcia, Agustin, Chang, Jeanne S., Chen, Ming Z., Choi, Chulho, Dow, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

2021

File:

PDF, 5.45 MB

2021

2

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure–activity relationships

Dennis Powell, Ariamala Gopalsamy, Yanong D. Wang, Nan Zhang, Miriam Miranda, John P. McGinnis, Sridhar K. Rabindran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 144 KB

english, 2007

3

Discovery of Pyrano[3,4- b ]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

Gopalsamy, Ariamala, Lim, Kitae, Ciszewski, Gregory, Park, Kaapjoo, Ellingboe, John W., Bloom, Jonathan, Insaf, Shabana, Upeslacis, Janis, Mansour, Tarek S., Krishnamurthy, Girija, Damarla, Murthy, Py

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

4

Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors

Ariamala Gopalsamy, Greg Ciszewski, Yongbo Hu, Frederick Lee, Larry Feldberg, Eileen Frommer, Steven Kim, Karen Collins, Donald Wojciechowicz, Robert Mallon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 551 KB

english, 2009

5

Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors

Dan M. Berger, Nancy Torres, Minu Dutia, Dennis Powell, Greg Ciszewski, Ariamala Gopalsamy, Jeremy I. Levin, Kyung-Hee Kim, Weixin Xu, James Wilhelm, YongBo Hu, Karen Collins, Larry Feldberg, Steven K

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 480 KB

english, 2009

6

Combinatorial Synthesis of Heterocycles: Solid-Phase Synthesis of 6-Amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine Derivatives

Gopalsamy, Ariamala, Yang, Hui

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 65 KB

english, 2001

7

Lipophilic bis-arylsulfonates as inhibitors of the CD4-gp120 interaction

Raymond J. Patch, John C. Roberts, Huai Gao, Zhan Shi, Ariamala Gopalsamy, Azis Kongsjahju, Kevin Daniels, Paul J. Kowalczyk, Marie-Rose van Schravendijk, Kristin A. Gordon, Peter V. Pallai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 355 KB

english, 1996

8

Differing pharmacological activities of thiazolidinone analogs at the FSH receptor

Brian J. Arey, Stephen D. Yanofsky, M. Claudia Pérez, Christopher P. Holmes, Jay Wrobel, Ariamala Gopalsamy, Panayiotis E. Stevis, Francisco J. López, Richard C. Winneker

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 362 KB

english, 2008

9

Parallel solid-phase synthesis of vitronectin receptor (αvβ3) inhibitors

Ariamala Gopalsamy, Hui Yang, John W Ellingboe, Kenneth L Kees, Jeanne Yoon, Richard Murrills

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 322 KB

english, 2000

10

Combinatorial Synthesis of Heterocycles: Solid-Phase Synthesis of 2-Amino-4(1 H )-quinazolinone Derivatives

Gopalsamy, Ariamala, Yang, Hui

Journal:

Journal of Combinatorial Chemistry

Year:

2000

Language:

english

File:

PDF, 53 KB

english, 2000

11

Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1

Ariamala Gopalsamy, Scott L. Kincaid, John W. Ellingboe, Thomas M. Groeling, Thomas M. Antrilli, Girija Krishnamurthy, Ann Aulabaugh, Gregory S. Friedrichs, David L. Crandall

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

12

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90

Gopalsamy, Ariamala, Shi, Mengxiao, Golas, Jennifer, Vogan, Erik, Jacob, Jaison, Johnson, Mark, Lee, Frederick, Nilakantan, Ramaswamy, Petersen, Roseann, Svenson, Kristin, Chopra, Rajiv, Tam, May S.,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 439 KB

english, 2008

13

An Efficient Synthesis of Dibenzo[ c , f ]-2,7-naphthyridine Ring System through Design of Experiments

Gopalsamy, Ariamala, Shi, Mengxiao, Nilakantan, Ramaswamy

Journal:

Organic Process Research & Development

Year:

2007

Language:

english

File:

PDF, 210 KB

english, 2007

14

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue

Fadeyi, Olugbeminiyi O., Hoth, Lise R., Choi, Chulho, Feng, Xidong, Gopalsamy, Ariamala, Hett, Erik C., Kyne, Robert E., Robinson, Ralph P., Jones, Lyn H.

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 786 KB

english, 2017

15

Design and Syntheses of 1,6-Naphthalene Derivatives as Selective HCMV Protease Inhibitors

Gopalsamy, Ariamala, Lim, Kitae, Ellingboe, John W., Mitsner, Boris, Nikitenko, Antonia, Upeslacis, Janis, Mansour, Tarek S., Olson, Matthew W., Bebernitz, Geraldine A., Grinberg, Diane, Feld, Boris,

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 106 KB

english, 2004

16

Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors

Yike Ni, Ariamala Gopalsamy, Derek Cole, Yonghan Hu, Rajiah Denny, Manus Ipek, Julie Liu, Julie Lee, J. Perry Hall, Michael Luong, Jean-Baptiste Telliez, Lih-Ling Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 763 KB

english, 2011

17

Design, Synthesis, and Study of 9-Substituted Ellipticine and 2-Methylellipticinium Analogs as Potential CNS-Selective Antitumor Agents

Anderson, Wayne K., Gopalsamy, Ariamala, Reddy, Peech S.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.29 MB

english, 1994

18

A novel and convenient mercury(II) mediated synthesis of chroman-4-ones

Gopalsamy, Ariamala, Balasubramanian, K. K.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1988

Language:

english

File:

PDF, 160 KB

english, 1988

19

Neopentyl ester protecting groups for arylsulfonic acids

John C. Roberts, Huai Gao, Ariamala Gopalsamy, Azis Kongsjahju, Raymond J. Patch

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 209 KB

english, 1997

20

Radical cyclisation of 4-(o-bromophenoxy)-2H-1-benzopyrans; an efficient synthesis of pterocarpans

Gopalsamy, Ariamala, Balasubramanian, K. K.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1988

Language:

english

File:

PDF, 150 KB

english, 1988

21

Combinatorial synthesis of heterocycles: Solid phase synthesis of 2-arylquinoline-4-carboxylic acid derivatives

Ariamala Gopalsamy, Peter V. Pallai

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 179 KB

english, 1997

22

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS

Xu, Hua, Hett, Erik C., Gopalsamy, Ariamala, Parikh, Mihir D., Geoghegan, Kieran F., Kyne, Robert E., Menard, Carol A., Narayanan, Arjun, Robinson, Ralph P., Johnson, Douglas S., Tones, Michael A., Jo

Journal:

Molecular BioSystems

Year:

2015

Language:

english

File:

PDF, 2.84 MB

english, 2015

23

Design and Synthesis of Oxadiazolidinediones as Inhibitors of Plasminogen Activator Inhibitor-1.

Ariamala Gopalsamy, Scott L. Kincaid, John W. Ellingboe, Thomas M. Groeling, Thomas M. Antrilli, Girija Krishnamurthy, Ann Aulabaugh, Gregory S. Friedrichs, David L. Crandall

Journal:

Year:

2004

File:

PDF, 33 KB

2004

24

ChemInform Abstract: Identification of Pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf Kinase Inhibitors.

Ariamala Gopalsamy, Greg Ciszewski, Yongbo Hu, Frederick Lee, Larry Feldberg, Eileen Frommer, Steven Kim, Karen Collins, Donald Wojciechowicz, Robert Mallon

Journal:

Year:

2009

File:

PDF, 26 KB

2009

25

Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells

Xu, Hua, Gopalsamy, Ariamala, Hett, Erik C., Salter, Shores, Aulabaugh, Ann, Kyne, Robert E., Pierce, Betsy, Jones, Lyn H.

Journal:

Organic & Biomolecular Chemistry

Year:

2016

Language:

english

File:

PDF, 355 KB

english, 2016

26

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region

Ariamala Gopalsamy, Hui Yang, John W. Ellingboe, Hwei-Ru Tsou, Nan Zhang, Erick Honores, Dennis Powell, Miriam Miranda, John P. McGinnis, Sridhar K. Rabindran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 122 KB

english, 2005

27

ChemInform Abstract: Hit to Lead Optimization of Pyrazolo[1,5-a]pyrimidines as B-Raf Kinase Inhibitors.

Ariamala Gopalsamy, et al. et al.

Journal:

Year:

2010

File:

PDF, 25 KB

2010

28

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

Hett, Erik C., Xu, Hua, Geoghegan, Kieran F., Gopalsamy, Ariamala, Kyne, Robert E., Menard, Carol A., Narayanan, Arjun, Parikh, Mihir D., Liu, Shenping, Roberts, Lee, Robinson, Ralph P., Tones, Michae

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

29

Identification of [(Naphthalene-1-carbonyl)-amino]-acetic Acid Derivatives as Nonnucleoside Inhibitors of HCV NS5B RNA Dependent RNA Polymerase.

Ariamala Gopalsamy, Kitae Lim, John W. Ellingboe, Girija Krishnamurthy, Mark Orlowski, Boris Feld, Marja van Zeijl, Anita Y. M. Howe

Journal:

Year:

2004

File:

PDF, 26 KB

2004

30

Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site

Gopalsamy, Ariamala, Chopra, Rajiv, Lim, Kitae, Ciszewski, Gregory, Shi, Mengxiao, Curran, Kevin J., Sukits, Steven F., Svenson, Kristine, Bard, Joel, Ellingboe, John W.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 189 KB

english, 2006

31

Novel Synthetic Approach to 6,7-Dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones.

Ariamala Gopalsamy, Mengxiao Shi

Journal:

Year:

2004

File:

PDF, 205 KB

2004

32

A facile selective acylation of castanospermine

Wayne K. Anderson, Robert A. Coburn, Ariamala Gopalsamy, Trevor J. Howe

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 147 KB

english, 1990

33

Novel Synthetic Approach to 6,7-Dihydro-5 H -imidazo[1,5-a]-pyrazin-8-ones

Gopalsamy, Ariamala, Shi, Mengxiao

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 62 KB

english, 2003

34

ChemInform Abstract: Synthesis of Pterocarpans by Means of a “Disfavored” 5-endo-trig Radical Cyclization Reaction.

Kalpathy Chidambareswaran Santhosh, Ariamala Gopalsamy, Kalputtu Kuppuswamy Balasubramanian

Journal:

Year:

2002

File:

PDF, 33 KB

2002

35

Pyrazolo[1,5-a]pyrimidin-7-yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region.

Ariamala Gopalsamy, Hui Yang, John W. Ellingboe, Hwei-Ru Tsou, Nan Zhang, Erick Honores, Dennis Powell, Miriam Miranda, John P. McGinnis, Sridhar K. Rabindran

Journal:

Year:

2005

File:

PDF, 21 KB

2005

36

Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure–activity relationships

Lori Krim Gavrin, Neal Green, Yonghan Hu, Kristin Janz, Neelu Kaila, Huan-Qiu Li, Steve Y. Tam, Jennifer R. Thomason, Ariamala Gopalsamy, Greg Ciszewski, John W. Cuozzo, J. Perry Hall, Sang Hsu, Jean-

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 126 KB

english, 2005

37

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA)

Gopalsamy, Ariamala, Narayanan, Arjun, Liu, Shenping, Parikh, Mihir D., Kyne, Robert E., Fadeyi, Olugbeminiyi, Tones, Michael A., Cherry, Jonathan J., Nabhan, Joseph F., LaRosa, Gregory, Petersen, Don

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

38

Discovery of Dibenzo[ c , f ][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors

Gopalsamy, Ariamala, Shi, Mengxiao, Boschelli, Diane H., Williamson, Robert, Olland, Andrea, Hu, Yongbo, Krishnamurthy, Girija, Han, Xin, Arndt, Kim, Guo, Bing

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 170 KB

english, 2007

39

Identification of Diarylsulfone Sulfonamides as Secreted Frizzled Related Protein-1 (sFRP-1) Inhibitors

Gopalsamy, Ariamala, Shi, Mengxiao, Stauffer, Barbara, Bahat, Ramesh, Billiard, Julia, Ponce-de-Leon, Helga, Seestaller-Wehr, Laura, Fukayama, Shoichi, Mangine, Annamarie, Moran, Robert, Krishnamurthy

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 82 KB

english, 2008

40

Selectivity determination of a small molecule chemical probe using protein microarray and affinity capture techniques

Hett, Erik C., Kyne, Robert E., Gopalsamy, Ariamala, Tones, Michael A., Xu, Hua, Thio, Guene L., Nolan, Edward, Jones, Lyn H.

Journal:

ACS Combinatorial Science

Year:

2016

Language:

english

File:

PDF, 979 KB

english, 2016

41

Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors

Ariamala Gopalsamy, Greg Ciszewski, Mengxiao Shi, Dan Berger, Yongbo Hu, Frederick Lee, Larry Feldberg, Eileen Frommer, Steven Kim, Karen Collins, Donald Wojciechowicz, Robert Mallon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 547 KB

english, 2009

42

Synthesis of Pterocarpans by Means of a “Disfavored” 5-endo-trig Radical Cyclization Reaction

Kalpathy Chidambareswaran Santhosh, Ariamala Gopalsamy, Kalputtu Kuppuswamy Balasubramanian

Journal:

European Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 285 KB

english, 2001

43

Facile acyl migration in 6-O-acylcastanospermine

Wayne K. Anderson, Ariamala Gopalsamy

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 180 KB

english, 1991

44

Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase

Ariamala Gopalsamy, Mengxiao Shi, Gregory Ciszewski, Kaapjoo Park, John W. Ellingboe, Mark Orlowski, Boris Feld, Anita Y.M. Howe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 108 KB

english, 2006

45

Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Ariamala Gopalsamy, Alexis Aplasca, Gregory Ciszewski, Kaapjoo Park, John W. Ellingboe, Mark Orlowski, Boris Feld, Anita Y.M. Howe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

46

Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-α converting enzyme (TACE) inhibitors

Kaapjoo Park, Ariamala Gopalsamy, Alexis Aplasca, John W. Ellingboe, Weixin Xu, Yuhua Zhang, Jeremy I. Levin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 513 KB

english, 2009

47

Identification of pyrimidine derivatives as hSMG-1 inhibitors

Gopalsamy, Ariamala, Bennett, Eric M., Shi, Mengxiao, Zhang, Wei-Guo, Bard, Joel, Yu, Ker

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.91 MB

english, 2012

48

Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Ariamala Gopalsamy, Kitae Lim, John W Ellingboe, Girija Krishnamurthy, Mark Orlowski, Boris Feld, Marja van Zeijl, Anita Y.M Howe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

49

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors

Ariamala Gopalsamy, Hui Yang, John W. Ellingboe, John C. McKew, Steve Tam, Diane Joseph-McCarthy, Wen Zhang, Marina Shen, James D. Clark

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 181 KB

english, 2006

50

B-Raf kinase inhibitors: Hit enrichment through scaffold hopping

Ariamala Gopalsamy, Mengxiao Shi, Yongbo Hu, Frederick Lee, Larry Feldberg, Eileen Frommer, Steven Kim, Karen Collins, Donald Wojciechowicz, Robert Mallon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 436 KB

english, 2010

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